Knowledge is critical to the survival of emerging economy multinationals (EMNEs), who are confronted by a lack of internal competitive capabilities and external challenges associated with diverse institutional environments. They thus must manage and orchestrate their knowledge globally for ultimate catch up. This article systematically reviews literature concerning EMNE knowledge management using content analysis of 93 articles in 17 leading journals across 7 major disciplines from 2000 to 2020. Applying the antecedent-process-outcome (APO) framework, we identify three major themes: knowledge-seeking strategy, knowledge transfer and innovation. We discuss knowledge frontier issues, directions for future scholarship, and avenues for greater interdisciplinary cross-fertilization.